The Scientific Harness

Harness the compounding power of every experiment.

Why Now

The missing foundation

The leap to closed-loop lab automation that can meaningfully accelerate discovery cannot happen without first structuring the knowledge that underlies it. That foundation does not yet exist. We are building it.

THE LABS OF THE FUTURE

CORTEX transforms today’s labs into the labs of the future

The labs of the future will be increasingly autonomous, giving scientists greater leverage to pursue discovery. CORTEX connects today’s laboratories to that future by turning accumulated knowledge into a living system that enables every experiment to build on what came before.

the PROBLEM

Modern biology is drowning in fragmentation

Source: Pharma IQ, 2022
“I have 1.8M files in a data lake with no structure, spanning years and different systems.”
Customer interview
49%
of bench scientists’ time is spent on manual data retrieval, cleansing, and transformation.
Source: Pharma IQ, 2022
THE BARRIER

The laboratory is not legible to AI

AI can retrieve the data, but without its scientific context, it cannot reason over it effectively.

Source: CORTEX primary research
97%
of 100+ scientists interviewed by CORTEX said AI does not understand their data.
Source: CORTEX primary research
“The only way that data is valuable is with its context.”
Customer interview
THE PROCESS

From fragmented records to scientific state

CORTEX connects the systems a laboratory already uses, resolves the relationships between them, and continuously builds the scientific context that AI can reason over.

Connect

01

CORTEX connects to ELNs, LIMS, instruments, files, archives, and other sources without requiring the laboratory to replace its existing infrastructure.

Resolve

02

CORTEX resolves entities, provenance, experiments, results, and decisions into a connected scientific representation.

Operate

03

CORTEX makes that scientific state usable by AI and captures verified outcomes back into the evolving state.

CORTEX SCIENTIFIC HARNESS

Everything an AI system needs to operate inside a real laboratory

CORTEX maintains scientific state, assembles task-specific context, governs interaction with the laboratory, and captures what happens next.

The CORTEX scientific harness A hexagonal harness around an AI agent with six parts: state, context, interfaces, control, security, and loop. Verified outcomes return to state. 01 · STATE the persistent scientific record of the laboratory 02 · CONTEXT task-specific context assembly 03 · INTERFACES retrieval · analysis · instruments · external systems 04 · CONTROL physical · procedural · implicit constraints 05 · SECURITY encryption · permissions · auditability 06 · LOOP verified outcomes return to state AI / AGENT any model, inside the harness
The CORTEX scientific harness A hexagonal harness around an AI agent with six parts: state, context, interfaces, control, security, and loop. Verified outcomes return to state. 01 · STATE persistent scientific record 02 CONTEXT 03 INTERFACES 04 CONTROL 05 SECURITY 06 · LOOP verified outcomes return to state AI / AGENT

State

01

The persistent scientific record of the laboratory: entities, evidence, relationships, history, and judgment.

Context

02

Task-specific context assembly. CORTEX selects and assembles the scientific context needed for a particular question, reasoning task, or action.

Interfaces

03

The mechanisms for retrieving knowledge, invoking analysis, and interacting with external systems: memory and knowledge retrieval, analytical tools, software, instruments, and external systems.

Control

04

Scientific control logic that accounts for the laboratory’s physical, procedural, and implicit constraints, so the agent operates within the actual boundaries of the scientific environment.

Security

05

Encryption, permissions, and auditability across data and actions. A boundary around the whole harness.

Loop

06

Every verified outcome updates the scientific state, compounding knowledge and creating feedback for what comes next.

BENCHMARKS

The same model performs better with CORTEX.

A controlled ablation using the same answer model with and without CORTEX.

PubMedQA
CORTEX improves answer accuracy and relevance.
Exact match
Model alone
71.0%
Model + CORTEX
85.9%
Improvement
+14.9 pts
Answer relevancy
Model alone
76.0%
Model + CORTEX
83.1%
Improvement
+7.1 pts
BioASQ
CORTEX improves both accepted-answer coverage and exact match.
Accepted answer present
Model alone
38.0%
Model + CORTEX
56.0%
Improvement
+18.0 pts
Exact match
Model alone
36.7%
Model + CORTEX
42.9%
Improvement
+6.2 pts
Retrieval

CORTEX retrieval against the common approach

Context precision and faithfulness of retrieved context, scored with RAGAS on PubMedQA.

Context precision
62.0%
94.2%
Basic vector RAG
CORTEX
+32.2 pts vs. basic vector RAG
Faithfulness
71.5%
88.7%
Basic vector RAG
CORTEX
+17.2 pts vs. basic vector RAG

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